Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0IH3Q
|
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| Former ID |
DNC000777
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| Drug Name |
ICRF-193
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [535604] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C12H18N4O4
|
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| Canonical SMILES |
CC(C(C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
|
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| InChI |
1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)/t7-,8+
|
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| InChIKey |
OBYGAPWKTPDTAS-OCAPTIKFSA-N
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| CAS Number |
CAS 21416-88-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10238334, 11121749, 11122229, 11362901, 11365463, 11368025, 11370993, 11370994, 11373626, 11376187, 14750955, 24896062, 26756840, 26756841, 29300050, 48169020, 48393605, 50012867, 50111449, 57339319, 75114731, 92310100, 99301012, 99302532, 103567119, 104407504, 128786916, 134339682, 134340112, 135073849, 141868838, 162248102, 226761503, 241039874, 252455824
|
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| Target and Pathway | |||||
| Target(s) | DNA topoisomerase II | Target Info | Inhibitor | [535604] | |
| References | |||||
| Ref 535604 | The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Exp Hematol. 2002 Nov;30(11):1273-82. | ||||
| Ref 535604 | The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Exp Hematol. 2002 Nov;30(11):1273-82. | ||||
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