Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0II5S
|
||||
| Former ID |
DNC004057
|
||||
| Drug Name |
DMP-728
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Discontinued in Phase 1 | [545470] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C25H36N8O7
|
||||
| Canonical SMILES |
CCC1C(=O)N(C(C(=O)NCC(=O)NC(C(=O)NCC2=CC=CC(=C2)C(=O)N1<br />)C(=O)O)CCCN=C(N)N)C.CS(=O)(=O)O
|
||||
| InChI |
1S/C24H34N8O7.CH4O3S/c1-3-15-22(37)32(2)16(8-5-9-27-24(25)26)20(35)29-12-17(33)31-18(23(38)39)21(36)28-11-13-6-4-7-14(10-13)19(34)30-15;1-5(2,3)4/h4,6-7,10,15-16,18H,3,5,8-9,11-12H2,1-2H3,(H,28,36)(H,29,35)(H,30,34)(H,31,33)(H,38,39)(H4,25,26,27);1H3,(H,2,3,4)/t15-,16+,18-;/m1./s1
|
||||
| InChIKey |
KKUJFDFDEDIZOU-PNQHFFRLSA-N
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | ||
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.