Drug Information

Drug General Information
Drug ID
D0IT6Q
Former ID
DCL000367
Drug Name
Tandutinib
Synonyms
CT 53518; CT53518; MLN 518; CT-53518; MLN-0518; MLN-518; MLN518, CT53518; Tandutinib (USAN/INN); (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide; 4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide; 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
Drug Type
Small molecular drug
Indication Glioblatoma; Gliosarcoma; Anaplastic mixed oligoastrocytoma [ICD9: 191; ICD10:C71] Discontinued in Phase 2 [541036], [547540]
Therapeutic Class
Anticancer Agents
Company
Millenium; Takeda
Structure
Download
2D MOL

3D MOL
Formula
C32H43N5O4
InChI
InChI=1S/C32H43N5O4/c1-24(2)41-26-10-8-25(9-11-26)34-32(38)37-19-17-36(18-20-37)29-12-13-33-28-23-31(30(39-3)22-27(28)29)40-21-7-16-35-14-5-4-6-15-35/h8-13,22-24H,4-7,14-21H2,1-3H3,(H,34,38)
InChIKey
SGVQMZVRLBDVCF-UHFFFAOYSA-N
CAS Number
CAS 387867-13-2
PubChem Compound ID
66524380
PubChem Substance ID
152106215, 162170728, 163914112, 178102322, 223396997
Target and Pathway
Target(s) FL cytokine receptor Target Info Inhibitor [536474], [551717]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
References
Ref 541036(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5695).
Ref 547540Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017148)
Ref 536474A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
Ref 551717Clinical pipeline report, company report or official report of Takeda (2009).

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