Drug General Information
Drug ID	D0IU2F
Former ID	DNC001581
Drug Name	NMED-160
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Discontinued in Phase 2	[547476]
Therapeutic Class	Analgesics
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Voltage-dependent N-type calcium channel	Target Info	Modulator
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Synaptic vesicle cycle
	Retrograde endocannabinoid signaling
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Taste transduction
	Type II diabetes mellitus
	Morphine addiction
	Nicotine addiction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	Endogenous cannabinoid signaling
	GABA-B receptor II signaling
Reactome	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways	Calcium Regulation in the Cardiac Cell
	Synaptic Vesicle Pathway
References
Ref 547476	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016715)

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