| Drug General Information |
| Drug ID |
D0IX4B
|
| Former ID |
DPR000124
|
| Drug Name |
AG-024322
|
| Synonyms |
AG-24322; N-[[5-[(3E)-3-(4,6-difluorobenzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Phase 1 |
[1]
|
|---|
| Company |
Pfizer
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H20F2N6
|
| Canonical SMILES |
CCNCC1=C(C(=CN=C1)C2=CC3=C(C=C2)NNC3=C4N=C5C=C(C=C(C5=N<br />4)F)F)C
|
| InChI |
1S/C23H20F2N6/c1-3-26-9-14-10-27-11-17(12(14)2)13-4-5-19-16(6-13)21(31-30-19)23-28-20-8-15(24)7-18(25)22(20)29-23/h4-8,10-11,26,30-31H,3,9H2,1-2H3/b23-21+
|
| InChIKey |
RBOKLZGCVRXGEP-XTQSDGFTSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
12015923, 16344089, 38371592, 43530197, 51321750, 114788634, 121183076, 139038218, 163642674, 198955582, 231582648, 252214681
|
| Target and Pathway |
| Target(s) |
Cell division protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Cell division protein kinase 4 |
Target Info |
Inhibitor |
[1]
|
| Cell division control protein 2 homolog |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
FoxO signaling pathway
|
|
Cell cycle
|
|
Oocyte meiosis
|
|
p53 signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Progesterone-mediated oocyte maturation
|
|
Hepatitis B
|
|
Measles
|
|
Herpes simplex infection
|
|
Epstein-Barr virus infection
|
|
Pathways in cancer
|
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Viral carcinogenesis
|
|
Prostate cancer
|
|
Small cell lung cancerhsa04110:Cell cycle
|
|
Tight junction
|
|
T cell receptor signaling pathway
|
|
HTLV-I infection
|
|
Pancreatic cancer
|
|
Glioma
|
|
Melanoma
|
|
Bladder cancer
|
|
Chronic myeloid leukemia
|
|
Small cell lung cancer
|
|
Non-small cell lung cancerhsa04110:Cell cycle
|
|
Gap junction
|
|
NetPath Pathway
|
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
EGFR1 Signaling Pathway
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RANKL Signaling PathwayNetPath_21:RANKL Signaling Pathway
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PANTHER Pathway
|
p53 pathway
|
|
p53 pathway feedback loops 2
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
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Signaling events mediated by PRL
|
|
p73 transcription factor network
|
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E2F transcription factor network
|
|
ATR signaling pathway
|
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mTOR signaling pathway
|
|
IL2-mediated signaling events
|
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FoxO family signaling
|
|
FOXM1 transcription factor network
|
|
BARD1 signaling events
|
|
p53 pathway
|
|
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
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Validated targets of C-MYC transcriptional activation
|
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ATF-2 transcription factor network
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Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
|
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PLK1 signaling events
|
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AP-1 transcription factor network
|
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Retinoic acid receptors-mediated signaling
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|
Reactome
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G0 and Early G1
|
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Activation of ATR in response to replication stress
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Regulation of APC/C activators between G1/S and early anaphase
|
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SCF(Skp2)-mediated degradation of p27/p21
|
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Senescence-Associated Secretory Phenotype (SASP)
|
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DNA Damage/Telomere Stress Induced Senescence
|
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Processing of DNA double-strand break ends
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G2 Phase
|
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Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
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p53-Dependent G1 DNA Damage Response
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Cyclin A:Cdk2-associated events at S phase entry
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Meiotic recombination
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Factors involved in megakaryocyte development and platelet productionR-HSA-2559580:Oxidative Stress Induced Senescence
|
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Oncogene Induced Senescence
|
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RMTs methylate histone arginines
|
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Transcriptional regulation of white adipocyte differentiation
|
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Ubiquitin-dependent degradation of Cyclin D1
|
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Cyclin D associated events in G1
|
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Meiotic recombinationR-HSA-110056:MAPK3 (ERK1) activation
|
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E2F mediated regulation of DNA replication
|
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Cyclin B2 mediated events
|
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Golgi Cisternae Pericentriolar Stack Reorganization
|
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
|
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Phosphorylation of the APC/C
|
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Phosphorylation of Emi1
|
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Condensation of Prophase Chromosomes
|
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MASTL Facilitates Mitotic Progression
|
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Resolution of Sister Chromatid Cohesion
|
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Condensation of Prometaphase Chromosomes
|
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Regulation of PLK1 Activity at G2/M Transition
|
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Activation of NIMA Kinases NEK9, NEK6, NEK7
|
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Loss of Nlp from mitotic centrosomes
|
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Recruitment of mitotic centrosome proteins and complexes
|
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Loss of proteins required for interphase microtubule organization?from the centrosome
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Recruitment of NuMA to mitotic centrosomes
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Depolymerisation of the Nuclear Lamina
|
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Anchoring of the basal body to the plasma membrane
|
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MAPK6/MAPK4 signaling
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G1/S-Specific Transcription
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G2/M DNA replication checkpoint
|
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
|
|
WikiPathways
|
DNA Damage Response
|
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ID signaling pathway
|
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DNA Replication
|
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G1 to S cell cycle control
|
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M/G1 Transition
|
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S Phase
|
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Meiotic Recombination
|
|
Aryl Hydrocarbon Receptor
|
|
ATM Signaling Pathway
|
|
Retinoblastoma (RB) in Cancer
|
|
Spinal Cord Injury
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Prostate Cancer
|
|
Signaling Pathways in Glioblastoma
|
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TSH signaling pathway
|
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Integrated Breast Cancer Pathway
|
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Integrated Cancer pathway
|
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Synthesis of DNA
|
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Regulation of DNA replication
|
|
Mitotic G2-G2/M phases
|
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Mitotic G1-G1/S phases
|
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Factors involved in megakaryocyte development and platelet production
|
|
Cell Cycle
|
|
APC/C-mediated degradation of cell cycle proteins
|
|
Cell Cycle Checkpoints
|
|
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
|
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Ovarian Infertility Genes
|
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PPAR Alpha Pathway
|
|
Bladder Cancer
|
|
Transcriptional Regulation of White Adipocyte Differentiation
|
|
TGF beta Signaling Pathway
|
|
MAP kinase activation in TLR cascade
|
|
RAF/MAP kinase cascade
|
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Mitotic Prophase
|
|
Mitotic Prometaphase
|
|
BMI1
|
|
Regulation of Microtubule Cytoskeleton
|
|
miRNA Regulation of DNA Damage Response
|
| References |
| REF 1 | Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. |
|---|
