Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0IZ7T
|
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| Former ID |
DIB010733
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| Drug Name |
YM-17E
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| Drug Type |
Small molecular drug
|
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| Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Discontinued in Phase 1 | [1] | ||
| Company |
Yamanouchi Pharmaceutical Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C40H58Cl2N6O2
|
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| Canonical SMILES |
C(=O)(N(Cc1cc(CN(C(=O)Nc2ccc(N(C)C)cc2)C2CCCCCC2)ccc1)C<br />1CCCCCC1)Nc1ccc(N(C)C)cc1.Cl.Cl
|
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| CAS Number |
CAS 124884-99-7
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002618) | ||||
| REF 2 | Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50. | ||||
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