Drug Information

Drug General Information
Drug ID
D0J0AE
Former ID
DCL000508
Drug Name
CP-945598
Synonyms
Otenabant; Otenabant hydrochloride; CP 945598; Otenabant hydrochloride (USAN); CP-945,598; Otenabant (USAN/INN); 1-(8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide monohydrochloride; 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-ethylamino-piperidine-4-carboxamide
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Discontinued in Phase 3 [536122]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C25H26Cl3N7O
Canonical SMILES
CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=C<br />C=C5Cl)C(=O)N.Cl
InChI
1S/C25H25Cl2N7O.ClH/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27;/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35);1H
InChIKey
KPYUQCJBZGQHPL-UHFFFAOYSA-N
CAS Number
CAS 677010-34-3
PubChem Compound ID
16223963
PubChem Substance ID
24906440, 28766292, 30224095, 81044372, 96026043, 134339096, 135253196, 135298705, 160676373, 161005265, 162011998, 162205202, 162259160, 163620721, 163686036, 164838600, 172917936, 185981738, 189614647, 198946927, 223400464, 229904576, 241376880, 251971061, 252157896, 252215197, 252664620
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [549974]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.