Drug Information

Drug General Information
Drug ID
D0J0KG
Former ID
DIB019765
Drug Name
DM-1451
Synonyms
DM 1451
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539735]
Structure
Download
2D MOL
Formula
C23H27Cl2N3O3
InChI
InChI=1S/C23H27Cl2N3O3/c24-22-19(6-7-20(29)23(22)25)28-12-10-27(11-13-28)9-1-2-14-31-17-5-3-16-4-8-21(30)26-18(16)15-17/h3,5-7,15,29H,1-2,4,8-14H2,(H,26,30)
InChIKey
YZIVLADPQQPFLO-UHFFFAOYSA-N
PubChem Compound ID
9847259
PubChem Substance ID
14809284, 24144121, 44945327, 50077051, 77986550, 135650196, 231417449, 245181729
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Agonist [525492]
5-hydroxytryptamine 7 receptor Target Info Agonist [525492]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04014:Ras signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and SerotoninPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
GPCRs, Other
References
Ref 539735(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 267).
Ref 525492Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27.

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