Drug Information

Drug General Information
Drug ID
D0J0ZS
Former ID
DAP000665
Drug Name
Gabapentin
Synonyms
Aclonium; GBN; Gabapen; Gabapentina; Gabapentine; Gabapentinium; Gabapentino; Gabapentinum; Gabapetin; Neurontin; Serada; Vultin; Apotex brand of gabapentin; Aventis brand of gabapentin; Gabapentin GR; Gabapentin Hexal; Gabapentin Stada; Gabapentino [Spanish]; Hexal brand of gabapentin; Novopharm brand of gabapentin; Parke Davis brand of gabapentin; Pfizer brand of gabapentin; Pharmascience brand of gabapentin; Ratiopharm brand of gabapentin; Stadapharm brand of gabapentin; GOE 2450; Go 3450; Apo-Gabapentin; DDS-2003; DM-1796; DM-5689; G-154; Gabapentin (Neurontin); Gabapentin-ratiopharm; Gabapentine [INN-French]; Gabapentino [INN-Spanish]; Gabapentinum [INN-Latin]; Goe-3450; Neurontin (TN); Novo-Gabapentin; PMS-Gabapentin; Warner-Lambert brand of gabapentin; Gabapentin [USAN:INN:BAN]; [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID; Gabapentin (JAN/USAN/INN); 1-(Aminomethyl)-cyclohexaneacetic acid; 1-(Aminomethyl)cyclohexaneacetic acid; 2-[1-(aminomethyl)cyclohexyl]acetic acid
Drug Type
Small molecular drug
Indication Partial seizures [ICD9: 345.4, 345.5; ICD10:G40.0, G40.2] Approved [536756], [540883]
Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 3 [540883], [551871]
Therapeutic Class
Analgesics
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C9H17NO2
InChI
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
InChIKey
UGJMXCAKCUNAIE-UHFFFAOYSA-N
CAS Number
CAS 60142-96-3
PubChem Compound ID
3446
PubChem Substance ID
855579, 3206533, 5651496, 7847398, 7887769, 7979342, 8028266, 8028269, 8152192, 10321252, 11111218, 11112806, 11113327, 11466889, 11468009, 11486558, 11528594, 12012796, 15171186, 17405144, 24278159, 25623436, 29222580, 46506529, 47291223, 47365305, 47515412, 47589087, 48035236, 48413201, 48416046, 49655262, 49698669, 49833701, 50100248, 50103936, 50103937, 50519620, 53777688, 56312982, 56365854, 57321804, 85174424, 85209452, 85231060, 87560508, 89649772, 90340599, 91146476, 92125867
SuperDrug ATC ID
N03AX12
SuperDrug CAS ID
cas=060142963
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Antagonist [536257]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 536756Use of second-generation antiepileptic drugs in the pediatric population. Paediatr Drugs. 2008;10(4):217-54.
Ref 540883(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5483).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536257Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons. Anesthesiology. 2006 Aug;105(2):325-33.

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