Drug Information

Drug General Information
Drug ID
D0J2WN
Former ID
DIB020651
Drug Name
PCCG-4
Synonyms
(2S,1'S,2'S,3?R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540294]
Structure
Download
2D MOL
Formula
C12H13NO4
InChI
InChI=1S/C12H13NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1
InChIKey
IFLWVSHRWAIVQF-KATARQTJSA-N
PubChem Compound ID
5311344
PubChem Substance ID
7980254, 11056449, 15764105, 39341031, 77576861, 103216980, 103969306, 114155871, 128160364, 162223138, 163058311, 178100366, 227532308
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Antagonist [534140]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 540294(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3335).
Ref 534140Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. J Med Chem. 1996 May 24;39(11):2259-69.

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