Drug General Information
Drug ID	D0J3QU
Former ID	DIB001817
Drug Name	ZD-7944
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[546304]
Company	Zeneca Group plc
Structure		Download 2D MOL 3D MOL
Formula	C31H34Cl2N2O2S
Canonical SMILES	C(=O)(N(C[C@H](c1cc(c(cc1)Cl)Cl)CCN1CCC(c2c(S(=O)C)cccc<br />2)CC1)C)c1ccccc1.Cl
CAS Number	CAS 161609-55-8
PubChem Compound ID	44351946
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Modulator	[526161]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546304	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007349)
Ref 526161	Discovery of novel, orally active dual NK1/NK2 antagonists. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2769-73.

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