Drug Information

Drug General Information
Drug ID
D0J4BF
Former ID
DIB019911
Drug Name
glucagon-(1-6)
Synonyms
glucagon 1-6
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538681]
Structure
Download
2D MOL
Formula
C29H41N9O10
InChI
InChI=1S/C29H41N9O10/c1-15(40)24(28(46)36-20(29(47)48)9-16-5-3-2-4-6-16)38-23(42)12-33-26(44)19(7-8-22(31)41)35-27(45)21(13-39)37-25(43)18(30)10-17-11-32-14-34-17/h2-6,11,14-15,18-21,24,39-40H,7-10,12-13,30H2,1H3,(H2,31,41)(H,32,34)(H,33,44)(H,35,45)(H,36,46)(H,37,43)(H,38,42)(H,47,48)/t15-,18+,19+,20+,21+,24+/m1/s1
InChIKey
VDWWLJRQDNTHJB-MXAMYCJDSA-N
PubChem Compound ID
194323
PubChem Substance ID
10261902, 33514981, 57397886, 76867238, 103200279, 103827386, 113458198, 135258751, 135652172, 162899100
Target and Pathway
Target(s) Glucagon receptor Target Info Agonist [531513]
KEGG Pathway Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 538681(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1147).
Ref 531513Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase. J Biol Chem. 1979 Jan 25;254(2):268-9.

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