Drug Information

Drug General Information
Drug ID
D0J4JA
Former ID
DIB020536
Drug Name
NIP
Synonyms
N-isopropyl-phenoxypropanolamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540861]
Formula
C12H19NO2
InChI
InChI=1S/C12H19NO2/c1-10(2)13-8-11(14)9-15-12-6-4-3-5-7-12/h3-7,10-11,13-14H,8-9H2,1-2H3
InChIKey
ONXLHKFGTDDVLQ-UHFFFAOYSA-N
PubChem Compound ID
3123920
PubChem Substance ID
3988437, 5182537, 9494595, 15488212, 25684124, 40905265, 41850760, 47850102, 48298851, 51393332, 57356064, 57919026, 88995591, 92157677, 103165259, 104054550, 104848618, 111738105, 117657268, 124677585, 125236425, 125420863, 127876190, 128836233, 134342087, 135556195, 135650720, 139709756, 141993304, 143400376, 144031927, 160832634, 160977351, 162361054, 163071725, 163397433, 163774711, 164216931, 169452363, 172648423, 179326932, 202567024, 223401284, 225167605, 232993592, 241144680, 242077980, 249857135, 250212816, 252067918
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [525440]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 546).
Ref 525440LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5.

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