Drug Information

Drug General Information
Drug ID
D0J5FK
Former ID
DIB019922
Drug Name
GNE-7915
Synonyms
GNE7915; GNE 7915
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532048]
Structure
Download
2D MOL
Formula
C19H21F4N5O3
InChI
InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChIKey
XCFLWTZSJYBCPF-UHFFFAOYSA-N
PubChem Compound ID
58539171
PubChem Substance ID
138914443, 163321410, 163347692, 163502368, 201248856, 210275720, 210281381, 233074324, 249565753, 249714964, 252160940, 252451829
Target and Pathway
Target(s) Dual specificity protein kinase TTK Target Info Inhibitor [532594]
leucine-rich repeat kinase 2 Target Info Inhibitor [532594]
KEGG Pathway Cell cycle
NetPath Pathway IL2 Signaling Pathway
WikiPathways Retinoblastoma (RB) in Cancer
References
Ref 532048Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33.
Ref 532594Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36.

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