TTD | Drug: D0J6JZ

Drug General Information
Drug ID	D0J6JZ
Former ID	DNC008399
Drug Name	MINALRESTAT
Drug Type	Small molecular drug
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Discontinued in Phase 3	[545360]
Structure		Download 2D MOL 3D MOL
Formula	C19H11BrF2N2O4
Canonical SMILES	C1C(=O)NC(=O)C12C3=C(C=CC(=C3)F)C(=O)N(C2=O)CC4=C(C=C(C<br />=C4)Br)F
InChI	1S/C19H11BrF2N2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-4-3-11(21)6-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27)
InChIKey	BMHZAHGTGIZZCT-UHFFFAOYSA-N
PubChem Compound ID	190816
Target and Pathway
Target(s)	Aldose reductase	Target Info	Modulator
BioCyc Pathway	Methylglyoxal degradation III
BioCyc Pathway	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 545360	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003006)

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Drug Information