Drug General Information
Drug ID	D0J6MS
Former ID	DIB016403
Drug Name	BIBU-251
Indication	Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Terminated	[545782]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(=O)N(CCN1CCC1CCNCC1)c1ccc(cc1)CCC(=O)O
CAS Number	CAS 698970-02-4
Target and Pathway
Target(s)	Glycoprotein IIb/IIIa receptor	Target Info	Modulator	[550135]
Reactome	Platelet degranulation
	Elastic fibre formation
	PECAM1 interactions
	Molecules associated with elastic fibres
	Integrin cell surface interactions
	Syndecan interactions
	ECM proteoglycans
	Integrin alphaIIb beta3 signaling
	GRB2:SOS provides linkage to MAPK signaling for Integrins
	p130Cas linkage to MAPK signaling for integrins
	VEGFA-VEGFR2 Pathway
	MAP2K and MAPK activation
WikiPathways	Focal Adhesion
	Hematopoietic Stem Cell Differentiation
	Human Complement System
	Extracellular matrix organization
	Arrhythmogenic Right Ventricular Cardiomyopathy
	Integrin-mediated Cell Adhesion
	L1CAM interactions
	Integrin cell surface interactions
	Integrin alphaIIb beta3 signaling
References
Ref 545782	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004683)
Ref 550135	CN patent application no. 101312747, Anticoagulant antithrombotic dual inhibitors comprising a biotin label.

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