Drug General Information
Drug ID
D0J6MS
Former ID
DIB016403
Drug Name
BIBU-251
Indication Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Terminated [545782]
Company
Boehringer Ingelheim Corp
Structure
Download
2D MOL

3D MOL

Canonical SMILES
C1(=O)N(CCN1CCC1CCNCC1)c1ccc(cc1)CCC(=O)O
CAS Number
CAS 698970-02-4
Target and Pathway
Target(s) Glycoprotein IIb/IIIa receptor Target Info Modulator [550135]
Reactome Platelet degranulation
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation
WikiPathways Focal Adhesion
Hematopoietic Stem Cell Differentiation
Human Complement System
Extracellular matrix organization
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
References
Ref 545782Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004683)
Ref 550135CN patent application no. 101312747, Anticoagulant antithrombotic dual inhibitors comprising a biotin label.

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