Drug Information

Drug General Information
Drug ID
D0J6XC
Former ID
DIB018046
Drug Name
tiratricol
Synonyms
TRIAC; 3,3',5-triiodothyroacetic acid
Drug Type
Small molecular drug
Indication Wound healing [ICD10:T14.0-T14.1] Clinical trial [539702]
Structure
Download
2D MOL
Formula
C14H9I3O4
InChI
InChI=1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
InChIKey
UOWZUVNAGUAEQC-UHFFFAOYSA-N
PubChem Compound ID
5803
PubChem Substance ID
827844, 827845, 827846, 827962, 855525, 4401016, 7885356, 8153574, 10321449, 11112109, 11466230, 11467350, 11485840, 14912191, 24900466, 26737090, 26737092, 26737109, 26737501, 29224836, 46504696, 46518914, 47349482, 47943909, 48019053, 48094654, 48426110, 49698385, 50100372, 50610406, 51091552, 53788806, 56261036, 57322967, 57654700, 85756745, 85788050, 91722578, 92125149, 103219116, 103913943, 104310301, 119526441, 121362089, 121362820, 124772192, 124881906, 124881907, 124881908, 126408229
Target and Pathway
Target(s) Thyroid hormone receptor alpha Target Info Agonist [531482]
Thyroid hormone receptor beta-1 Target Info Agonist [531482]
KEGG Pathway Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Endochondral Ossification
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Nuclear Receptors
References
Ref 539702(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2637).
Ref 531482Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34.

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