Drug Information

Drug General Information
Drug ID
D0J9GD
Former ID
DNC003318
Drug Name
Mevastatin
Drug Type
Small molecular drug
Indication Discovery agent Terminated [540037], [545220]
Structure
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2D MOL

3D MOL
Formula
C23H34O5
InChI
InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChIKey
AJLFOPYRIVGYMJ-INTXDZFKSA-N
CAS Number
CAS 73573-88-3
PubChem Compound ID
64715
PubChem Substance ID
7846932, 7978987, 8189253, 12015427, 14756488, 14780729, 17405315, 24278540, 24820212, 25819930, 26719712, 26759157, 43121594, 46386660, 47574453, 47944886, 49896293, 53777860, 53790805, 56468435, 57288790, 57315124, 71821891, 78233515, 85787615, 89850273, 90340823, 91614978, 92304233, 92308676, 92308746, 103241784, 103923731, 104331841, 117549691, 119525148, 121361574, 124659149, 124800281, 135021782, 135650602, 135727287, 135969249, 137101020, 142413177, 144089061, 144205093, 152134131, 160809187, 162023089
Target and Pathway
Target(s) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Antagonist [551386]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretion
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540037(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3031).
Ref 545220Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002490)
Ref 551386Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5.

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