Drug General Information
Drug ID	D0J9SS
Former ID	DNC011764
Drug Name	6-Nitro-2-(3-nitro-phenyl)-chromen-4-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551290]
Structure		Download 2D MOL 3D MOL
Formula	C15H8N2O6
Canonical SMILES	C1=CC(=CC(=C1)[N+](=O)[O-])C2=CC(=O)C3=C(O2)C=CC(=C3)[N<br />+](=O)[O-]
InChI	1S/C15H8N2O6/c18-13-8-15(9-2-1-3-10(6-9)16(19)20)23-14-5-4-11(17(21)22)7-12(13)14/h1-8H
InChIKey	CNVQMRWAJHEFGZ-UHFFFAOYSA-N
PubChem Compound ID	127714
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[551290]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[551290]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[551290]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 551290	6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995).
Ref 551290	6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995).

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