Drug General Information
Drug ID	D0JJ8A
Former ID	DIB016286
Drug Name	CaV2.2 blocker
Synonyms	CaV2.2 blocker (pain); CaV2.2 blocker (pain), Merck & Co
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Investigative	[552036]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	CC(C)(S(=O)(=O)c1cc(cc(C(F)(F)F)c1)F)C1CCN(C(=O)c2ncc(C<br />(F)(F)F)cc2S(=O)(=O)C)CC1
Target and Pathway
Target(s)	Voltage-dependent N-type calcium channel	Target Info	Blocker	[543870]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Synaptic vesicle cycle
	Retrograde endocannabinoid signaling
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Taste transduction
	Type II diabetes mellitus
	Morphine addiction
	Nicotine addiction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	Endogenous cannabinoid signaling
	GABA-B receptor II signaling
Reactome	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways	Calcium Regulation in the Cardiac Cell
	Synaptic Vesicle Pathway
References
Ref 552036	A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors. Assay Drug Dev Technol. 2008 Apr;6(2):195-212
Ref 543870	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 533).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.