Drug Information

Drug General Information
Drug ID
D0JK0I
Former ID
DIB020755
Drug Name
prenalterol
Synonyms
CGP 7760B
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540792]
Structure
Download
2D MOL
Formula
C12H19NO3
InChI
InChI=1S/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3/t11-/m0/s1
InChIKey
ADUKCCWBEDSMEB-NSHDSACASA-N
PubChem Compound ID
42396
PubChem Substance ID
9736, 7980379, 8177605, 12015540, 15121536, 34707931, 50005694, 50266270, 57312677, 96099954, 103760800, 104339535, 117535178, 127391955, 135260404, 135650853, 137273831, 163693565, 163853022, 164150591, 164232824, 172860850, 179150694, 184547136, 198954444, 223440735, 223533435, 224855346, 225249491, 226599076, 252356181
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [533129]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540792(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 537).
Ref 533129Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol. 1989 Mar;35(3):295-303.

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