Drug Information

Drug General Information
Drug ID
D0JO8Z
Former ID
DNAP001648
Drug Name
Fosfestrol
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Approved [551871]
Structure
Download
2D MOL

3D MOL
Formula
C18H22O8P2
Canonical SMILES
CCC(=C(CC)C1=CC=C(C=C1)OP(=O)(O)O)C2=CC=C(C=C2)OP(=O)(O<br />)O
InChI
1S/C18H22O8P2/c1-3-17(13-5-9-15(10-6-13)25-27(19,20)21)18(4-2)14-7-11-16(12-8-14)26-28(22,23)24/h5-12H,3-4H2,1-2H3,(H2,19,20,21)(H2,22,23,24)/b18-17+
InChIKey
NLORYLAYLIXTID-ISLYRVAYSA-N
CAS Number
CAS 13425-53-1
PubChem Compound ID
3032325
PubChem Substance ID
10345, 7848009, 7979318, 10047183, 15329796, 36076580, 50047749, 50125929, 57352633, 76531220, 103770581, 111631913, 115354413, 126603657, 131549784, 134931955, 134977604, 137156414, 137545234, 143449629, 144206347, 162059604, 162172997, 163693541, 172858626, 179226216, 179316276, 184546059, 198986325, 223439533, 223535890, 225040070, 226400299, 241090562, 252350068
SuperDrug ATC ID
G03CB02; G03CC05; L02AA04
Target and Pathway
Target(s) Estrogen receptor Target Info Modulator [527592], [530110]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 527592Assay of the synthetic estrogen fosfestrol in pharmaceutical formulations using capillary electrophoresis. J Pharm Biomed Anal. 2005 Sep 15;39(3-4):559-63.
Ref 530110Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009 Jul;109(7):3012-43.

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