Drug General Information
Drug ID	D0K1EG
Former ID	DIB007536
Drug Name	QAV-680
Indication	Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4]		Phase 2	[523004]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Putative G-protein coupled receptor 44	Target Info	Antagonist	[532474]
Reactome	Prostanoid ligand receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523004	ClinicalTrials.gov (NCT01103037) Efficacy, Safety and Pharmacokinetics of QAV680 Versus Placebo in Patients With Asthma. U.S. National Institutes of Health.
Ref 532474	Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91.

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