Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K2CR
|
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| Former ID |
DIB015003
|
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| Drug Name |
Nemorubicin
|
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| Synonyms |
Nemorubicinol; FCE-23762; PNU-152243; PNU-156685; PNU-156686; PNU-159682
|
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Preclinical | [1] | ||
| Company |
Pharmacia & Upjohn AB
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C32H37NO13
|
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| Canonical SMILES |
c12c(C(=O)c3c(C1=O)cccc3OC)c(c1c(c2O)C[C@](C[C@@H]1O[C@<br />H]1C[C@H](N2C[C@H](OCC2)OC)[C@@H]([C@@H](O1)C)O)(C(=O)C<br />O)O)O
|
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| CAS Number |
CAS 108852-90-0
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA topoisomerase II | Target Info | Modulator | [2] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012041) | ||||
| REF 2 | The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)(2), d(CGATCG)(2) and d(CGCGCG)(2) shows a strong but reversible binding to G:C base pairs. Bioorg Med Chem. 2012 Dec 15;20(24):6979-88. | ||||
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