Drug Information

Drug General Information
Drug ID
D0K2CR
Former ID
DIB015003
Drug Name
Nemorubicin
Synonyms
Nemorubicinol; FCE-23762; PNU-152243; PNU-156685; PNU-156686; PNU-159682
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Preclinical [547011]
Company
Pharmacia & Upjohn AB
Structure
Download
2D MOL

3D MOL
Formula
C32H37NO13
Canonical SMILES
c12c(C(=O)c3c(C1=O)cccc3OC)c(c1c(c2O)C[C@](C[C@@H]1O[C@<br />H]1C[C@H](N2C[C@H](OCC2)OC)[C@@H]([C@@H](O1)C)O)(C(=O)C<br />O)O)O
CAS Number
CAS 108852-90-0
PubChem Compound ID
65907
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [532120]
References
Ref 547011Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012041)
Ref 532120The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)(2), d(CGATCG)(2) and d(CGCGCG)(2) shows a strong but reversible binding to G:C base pairs. Bioorg Med Chem. 2012 Dec 15;20(24):6979-88.

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