Drug Information
Drug General Information | |||||
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Drug ID |
D0K2QG
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Former ID |
DIB013626
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Drug Name |
DASANTAFIL
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Synonyms |
Dasantafil < USAN; Prop INN >; SCH-446132; 7-(3-Bromo-4-methoxybenzyl)-1-ethyl-8-[2(R)-hydroxycyclopent-1(R)-ylamino]-3-(2-hydroxyethyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 7-(3-Bromo-4-methoxybenzyl)-1-ethyl-8-[2(R)-hydroxycyclopent-1(R)-ylamino]-3-(2-hydroxyethyl)xanthine
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Drug Type |
Small molecular drug
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Indication | Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] | Discontinued in Phase 2 | [547746] | ||
Structure |
Download2D MOL |
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Formula |
C22H28BrN5O5
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Canonical SMILES |
CCN1C(=O)N(CCO)c2nc(N[C@@H]3CCC[C@H]3O)n(Cc4ccc(OC)c(Br<br />)c4)c2C1=O
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InChI |
1S/C22H28BrN5O5/c1-3-26-20(31)18-19(27(9-10-29)22(26)32)25-21(24-15-5-4-6-16(15)30)28(18)12-13-7-8-17(33-2)14(23)11-13/h7-8,11,15-16,29-30H,3-6,9-10,12H2,1-2H3,(H,24,25)/t15-,16-/m1/s1
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InChIKey |
RCJYGWGQCPDYSL-HZPDHXFCSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [551871] | |
KEGG Pathway | Purine metabolism | ||||
cGMP-PKG signaling pathway | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
Reactome | cGMP effects | ||||
References |
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