Drug General Information
Drug ID
D0K2QG
Former ID
DIB013626
Drug Name
DASANTAFIL
Synonyms
Dasantafil < USAN; Prop INN >; SCH-446132; 7-(3-Bromo-4-methoxybenzyl)-1-ethyl-8-[2(R)-hydroxycyclopent-1(R)-ylamino]-3-(2-hydroxyethyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 7-(3-Bromo-4-methoxybenzyl)-1-ethyl-8-[2(R)-hydroxycyclopent-1(R)-ylamino]-3-(2-hydroxyethyl)xanthine
Drug Type
Small molecular drug
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Discontinued in Phase 2 [547746]
Structure
Download
2D MOL

3D MOL

Formula
C22H28BrN5O5
Canonical SMILES
CCN1C(=O)N(CCO)c2nc(N[C@@H]3CCC[C@H]3O)n(Cc4ccc(OC)c(Br<br />)c4)c2C1=O
InChI
1S/C22H28BrN5O5/c1-3-26-20(31)18-19(27(9-10-29)22(26)32)25-21(24-15-5-4-6-16(15)30)28(18)12-13-7-8-17(33-2)14(23)11-13/h7-8,11,15-16,29-30H,3-6,9-10,12H2,1-2H3,(H,24,25)/t15-,16-/m1/s1
InChIKey
RCJYGWGQCPDYSL-HZPDHXFCSA-N
PubChem Compound ID
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [551871]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 547746Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018967)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.