Drug General Information
Drug ID	D0K2UA
Former ID	DNC006582
Drug Name	4-tert-butyl-N-(2-isopropylphenyl)thiazol-2-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528047]
Structure		Download 2D MOL 3D MOL
Formula	C16H22N2S
Canonical SMILES	CC(C)C1=CC=CC=C1NC2=NC(=CS2)C(C)(C)C
InChI	1S/C16H22N2S/c1-11(2)12-8-6-7-9-13(12)17-15-18-14(10-19-15)16(3,4)5/h6-11H,1-5H3,(H,17,18)
InChIKey	XGRAMFLJGHKCSV-UHFFFAOYSA-N
PubChem Compound ID	44411266
Target and Pathway
Target(s)	C-Cchemokine receptor type 4	Target Info	Inhibitor	[528047]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Viral carcinogenesis
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528047	Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.
Ref 528047	Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.

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