Drug Information

Drug General Information
Drug ID
D0K3LX
Former ID
DIB016993
Drug Name
RNAPc2
Synonyms
RAcAPc2; Recombinant nematode anticoagulant protein, Dendreon; Recombinant nematode anticoagulant protein, Nuvelo
Indication Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Discontinued in Phase 2 [546176]
Company
Dendreon San Diego LLC
Target and Pathway
Target(s) Coagulation factor VII Target Info Modulator [529895]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Angiogenesis
Blood coagulation
PathWhiz Pathway Coagulation
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
Extrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
Circadian Clock
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 546176Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006762)
Ref 529895rNAPc2 inhibits colorectal cancer in mice through tissue factor. Clin Cancer Res. 2009 Jan 1;15(1):208-16.

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