Drug Information

Drug General Information
Drug ID
D0K4PK
Former ID
DNC007349
Drug Name
1-guanidino-7-isoquinolinesulphonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528796]
Structure
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2D MOL

3D MOL
Formula
C10H11N5O2S
Canonical SMILES
C1=CC(=CC2=C1C=CN=C2N=C(N)N)S(=O)(=O)N
InChI
1S/C10H11N5O2S/c11-10(12)15-9-8-5-7(18(13,16)17)2-1-6(8)3-4-14-9/h1-5H,(H2,13,16,17)(H4,11,12,14,15)
InChIKey
NRVVFOKWKSWIIV-UHFFFAOYSA-N
PubChem Compound ID
16658352
Target and Pathway
Target(s) Urokinase-type plasminogen activator Target Info Inhibitor [528796]
Plasminogen Target Info Inhibitor [528796]
KEGG Pathway NF-kappa B signaling pathway
Complement and coagulation cascades
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancerhsa04080:Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
Influenza A
NetPath Pathway IL2 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
CCKR signaling map STP00011:Blood coagulation
Pathway Interaction Database Beta1 integrin cell surface interactions
E2F transcription factor network
Beta3 integrin cell surface interactions
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
amb2 Integrin signaling
ATF-2 transcription factor network
AP-1 transcription factor network
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
FGF signaling pathwayangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
Syndecan-4-mediated signaling events
PathWhiz Pathway Coagulation
Reactome Dissolution of Fibrin ClotR-HSA-114608:Platelet degranulation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin Clot
WikiPathways DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Complement and Coagulation Cascades
Endochondral Ossification
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Blood Clotting Cascade
Dissolution of Fibrin Clot
Osteopontin SignalingWP558:Complement and Coagulation Cascades
Human Complement System
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 528796J Med Chem. 2007 May 17;50(10):2341-51. Epub 2007 Apr 21.Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.
Ref 528796J Med Chem. 2007 May 17;50(10):2341-51. Epub 2007 Apr 21.Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.

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