Drug Information

Drug General Information
Drug ID
D0K4TV
Former ID
DNC014689
Drug Name
5-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534469]
Structure
Download
2D MOL

3D MOL
Formula
C16H14N2O
Canonical SMILES
CC1=C2C(=O)C=C(NC2=NC=C1)C3=CC(=CC=C3)C
InChI
1S/C16H14N2O/c1-10-4-3-5-12(8-10)13-9-14(19)15-11(2)6-7-17-16(15)18-13/h3-9H,1-2H3,(H,17,18,19)
InChIKey
ZLZNSSZWWMBAMD-UHFFFAOYSA-N
PubChem Compound ID
385182
Target and Pathway
Target(s) Tubulin Target Info Inhibitor [534469]
Tubulin beta Target Info Inhibitor [534469]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 534469J Med Chem. 1997 Sep 12;40(19):3049-56.Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
Ref 534469J Med Chem. 1997 Sep 12;40(19):3049-56.Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.