Drug General Information
Drug ID	D0K4UW
Former ID	DIB014304
Drug Name	Imitrodast
Synonyms	Logran; CS-518; RS-5186
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[544584]
Company	Sankyo Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C13H12N2O2S
Canonical SMILES	c12c(cc(s1)Cn1ccnc1)CCC(=C2)C(=O)[O-].[Na+]
CAS Number	CAS 113817-57-5
PubChem Compound ID	65922
Target and Pathway
Target(s)	Thromboxane-A synthase	Target Info	Inhibitor	[533430]
BioCyc Pathway	C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
References
Ref 544584	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000225)
Ref 533430	RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. Thromb Res. 1988 Sep 1;51(5):507-20.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.