Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K5EE
|
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| Former ID |
DIB012791
|
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| Drug Name |
S-33084
|
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| Synonyms |
Benzopyrano[3,4-c]pyrrole derivs, Servier
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| Drug Type |
Small molecular drug
|
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| Indication | Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] | Preclinical | [1], [2] | ||
| Company |
Servier
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C29H29N3O2
|
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| InChI |
InChI=1S/C29H29N3O2/c30-17-21-8-13-28-26(16-21)27-19-32(18-25(27)20-34-28)15-5-4-14-31-29(33)24-11-9-23(10-12-24)22-6-2-1-3-7-22/h1-3,6-13,16,25,27H,4-5,14-15,18-20H2,(H,31,33)/t25-,27+/m1/s1
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| InChIKey |
QQJHRQZZCNYDMX-VPUSJEBWSA-N
|
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| CAS Number |
CAS 273203-30-8
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | D(3) dopamine receptor | Target Info | Modulator | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Dopaminergic synapse | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 129). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013394) | ||||
| REF 3 | S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther. 2000 Jun;293(3):1063-73. | ||||
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