Drug Information

Drug General Information
Drug ID
D0K6UK
Former ID
DNC001265
Drug Name
Saframycin A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535941]
Structure
Download
2D MOL

3D MOL
Formula
C29H30N4O8
Canonical SMILES
CC1=C(C(=O)C2=C(C1=O)CC3C4C5=C(CC(N4C)C(N3C2CNC(=O)C(=O<br />)C)C#N)C(=O)C(=C(C5=O)OC)C)OC
InChI
1S/C29H30N4O8/c1-11-23(35)14-8-17-22-21-15(24(36)12(2)28(41-6)26(21)38)7-16(32(22)4)18(9-30)33(17)19(10-31-29(39)13(3)34)20(14)25(37)27(11)40-5/h16-19,22H,7-8,10H2,1-6H3,(H,31,39)/t16-,17+,18+,19-,22-/m0/s1
InChIKey
JNEGMBHBUAJRSX-TZDBLYRBSA-N
CAS Number
CAS 66082-27-7
PubChem Compound ID
50909125
PubChem Substance ID
111637107
Target and Pathway
Target(s) Glyceraldehyde 3-phosphate dehydrogenase, muscle Target Info Binder [535941]
BioCyc Pathway Superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Gluconeogenesis
NADH repair
Glycolysis
KEGG Pathway Glycolysis / Gluconeogenesis
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Biosynthesis of amino acids
HIF-1 signaling pathway
Alzheimer's disease
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Glycolysis
Huntington disease
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Glycerol Phosphate Shuttle
Glycolysis
Gluconeogenesis
Mitochondrial Electron Transport Chain
Warburg Effect
Reactome Glycolysis
Gluconeogenesis
WikiPathways SIDS Susceptibility Pathways
Glycolysis and Gluconeogenesis
Alzheimers Disease
Cori Cycle
References
Ref 535941Identification of GAPDH as a protein target of the saframycin antiproliferative agents. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6. Epub 2004 Apr 12.
Ref 535941Identification of GAPDH as a protein target of the saframycin antiproliferative agents. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6. Epub 2004 Apr 12.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.