Drug Information

Drug General Information
Drug ID
D0K7NQ
Former ID
DAP001324
Drug Name
Colistin
Synonyms
Colistin sulphate; Polymyxin E; Colistin sulfate, nonsterile; Polymyxin E. Sulfate; Coly-Mycin M Parenteral (TN)
Drug Type
Small molecular drug
Indication Infections by gram-negative bacilli particularly Pseudomonas aeruginosa [ICD10:B96.5] Approved [551871]
Therapeutic Class
Antibiotics
Company
Parkdale Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C52H98N16O13
Canonical SMILES
CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1<br />CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O<br />)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O
InChI
1S/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1
InChIKey
YKQOSKADJPQZHB-QNPLFGSASA-N
CAS Number
CAS 1264-72-8
PubChem Compound ID
5311054
PubChem Substance ID
615200, 7978985, 11056238, 39340783, 46505467, 50873188, 96099852, 114155157, 124766320, 134338539, 137260964, 160964145, 162224764, 228138971, 242084741
SuperDrug ATC ID
A07AA10; J01XB01
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Dihydropteroate synthetase Target Info Binder [534902]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534902Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.

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