Drug Information

Drug General Information
Drug ID
D0K8BZ
Former ID
DNC007123
Drug Name
N-(4-phenylsulfamoyl-naphthalen-1-yl)-benzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528647]
Structure
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2D MOL

3D MOL
Formula
C23H18N2O3S
Canonical SMILES
C1=CC=C(C=C1)C(=O)NC2=CC=C(C3=CC=CC=C32)S(=O)(=O)NC4=CC<br />=CC=C4
InChI
1S/C23H18N2O3S/c26-23(17-9-3-1-4-10-17)24-21-15-16-22(20-14-8-7-13-19(20)21)29(27,28)25-18-11-5-2-6-12-18/h1-16,25H,(H,24,26)
InChIKey
WLKYPFNFQJMVGH-UHFFFAOYSA-N
PubChem Compound ID
11774008
Target and Pathway
Target(s) C-C chemokine receptor type 8 Target Info Inhibitor [528647]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528647J Med Chem. 2007 Feb 8;50(3):566-84.Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.
Ref 528647J Med Chem. 2007 Feb 8;50(3):566-84.Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.

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