Drug Information

Drug General Information
Drug ID
D0K8HF
Former ID
DIB009940
Drug Name
PLD-147
Synonyms
LA-12; (OC-6-43)Bis(acetato-kappaO)amminedichloro(adamant-1-ylamine)platinum
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 1 [547679]
Structure
Download
2D MOL

3D MOL
Formula
C11H12N2O3
Canonical SMILES
CC1C2=C(CC(=O)N1)C(=CN=C2)C(=O)OC
InChI
1S/C11H12N2O3/c1-6-8-4-12-5-9(11(15)16-2)7(8)3-10(14)13-6/h4-6H,3H2,1-2H3,(H,13,14)/t6-/m0/s1
InChIKey
KSMITTDZTTZFML-LURJTMIESA-N
CAS Number
CAS 250611-20-2
PubChem Compound ID
442551
PubChem Substance ID
12171, 36886070, 50832007, 104627911, 162810271, 223440073
Target and Pathway
Target(s) Human DNA Target Info Binder [530976]
References
Ref 547679Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018371)
Ref 530976The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin. Mol Cancer. 2010 Jun 15;9:147.

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