Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K8KJ
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| Former ID |
DIB016419
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| Drug Name |
DuP-129
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| Synonyms |
ACAT inhibitors, Du Pont
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| Indication | Hypercholesterolemia [ICD10:E78] | Terminated | [1] | ||
| Company |
Bristol-Myers Squibb Pharma Co
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C1(N=C(N([C@@H]1CC(=O)C1CCCCC1)C)c1ccc(cc1)F)(C(F)(F)F)<br />C(F)(F)F
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| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003587) | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592). | ||||
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