Drug Information

Drug General Information
Drug ID
D0K8LM
Former ID
DNC000356
Drug Name
BSO
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534959], [535104]
Structure
Download
2D MOL

3D MOL
Formula
C8H18N2O3S
Canonical SMILES
CCCCS(=N)(=O)CCC(C(=O)O)N
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
InChIKey
KJQFBVYMGADDTQ-UHFFFAOYSA-N
PubChem Compound ID
21157
PubChem Substance ID
7149, 470523, 611290, 3152422, 5424130, 7979959, 8137337, 8165593, 11407220, 15196004, 17404794, 24278264, 24851509, 26612746, 26747459, 29288576, 47662984, 47960442, 49896016, 49896017, 50105970, 50105971, 53777337, 53790918, 57330818, 57647786, 79184104, 85084416, 85230938, 88813849, 90341675, 92303559, 92729989, 104352517, 118498162, 121361107, 123099040, 124749557, 124879403, 124879404, 124969077, 125371253, 125539970, 134339803, 134984677, 135057287, 137019747, 141444299, 143829180, 162079115
Target and Pathway
Target(s) Glutamate--cysteine ligase regulatorysubunit Target Info Inhibitor [534959], [535104]
KEGG Pathway Glutathione metabolism
Metabolic pathways
PathWhiz Pathway Glutamate Metabolism
Glutathione Metabolism
Cysteine Metabolism
WikiPathways Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
Metabolism of amino acids and derivatives
Trans-sulfuration and one carbon metabolism
Trans-sulfuration pathway
Phase II conjugation
Glutathione metabolism
References
Ref 534959Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione. Biochem J. 2000 Mar 1;346 Pt 2:545-52.
Ref 535104The gamma-glutamylcysteine synthetase of Onchocerca volvulus. Mol Biochem Parasitol. 2000 Dec;111(2):243-51.
Ref 534959Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione. Biochem J. 2000 Mar 1;346 Pt 2:545-52.
Ref 535104The gamma-glutamylcysteine synthetase of Onchocerca volvulus. Mol Biochem Parasitol. 2000 Dec;111(2):243-51.

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