Drug Information

Drug General Information
Drug ID
D0K8NR
Former ID
DCL000425
Drug Name
AMG 386
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 3 [523327], [543118]
Company
Amgen
Structure
Download
2D MOL

3D MOL
Formula
Na
Canonical SMILES
[Na]
InChI
1S/Na
InChIKey
KEAYESYHFKHZAL-UHFFFAOYSA-N
PubChem Compound ID
5360545
PubChem Substance ID
5326610, 8146756, 10534514, 15170295, 15237733, 24845275, 24848128, 24853383, 24854694, 24855921, 24857014, 24857016, 24868737, 24871915, 24881721, 24886151, 24886235, 24888697, 33088985, 39384005, 50046431, 50074094, 53788965, 57362018, 57647078, 57648086, 57652275, 57652326, 77905220, 83620210, 88826695, 114148349, 117376386, 125809647, 126675963, 131325865, 134339053, 134339153, 134339154, 134339155, 134339359, 134339385, 134339536, 134339884, 134340144, 134987874, 134988506, 137102243, 137156482, 139072878
Target and Pathway
Target(s) Angiopoietin-2 Target Info Modulator [1572591]
Angiopoietin-1 Target Info Modulator [1572591]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathwayhsa04014:Ras signaling pathway
PI3K-Akt signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
FSH Signaling Pathway
PANTHER Pathway AngiogenesisP00005:Angiogenesis
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signalingangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
SHP2 signaling
Reactome Tie2 SignalingR-HSA-210993:Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Cell surface interactions at the vascular wallWP1794:Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 523327ClinicalTrials.gov (NCT01281254) TRINOVA-2: Trebananib in Ovarian Cancer-2. U.S. National Institutes of Health.
Ref 543118(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8414).
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.