Drug Information

Drug General Information
Drug ID
D0K8TI
Former ID
DNCL002967
Drug Name
Ranirestat
Synonyms
AS-3201
Drug Type
Small molecular drug
Indication Diabetic neuropathy [ICD9: 250, 250.6, 356.0, 356.8; ICD10:E11.40] Phase 3 [521626]
Company
Eisai
Structure
Download
2D MOL

3D MOL
Formula
C17H11BrFN3O4
Canonical SMILES
C1C(=O)NC(=O)C12C(=O)N(C(=O)C3=CC=CN23)CC4=C(C=C(C=C4)B<br />r)F
InChI
1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
InChIKey
QCVNMNYRNIMDKV-QGZVFWFLSA-N
PubChem Compound ID
153948
PubChem Substance ID
10251912, 12014810, 14880259, 14904801, 46230177, 47208060, 51012575, 53789842, 57347942, 103367870, 103961847, 104437619, 135110737, 137144707, 142493404, 175426978, 198989475, 226813947, 247325284
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [543707]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 521626ClinicalTrials.gov (NCT00101426) Safety and Efficacy of AS-3201 in the Treatment of Diabetic Sensorimotor Polyneuropathy. U.S. National Institutes of Health.
Ref 543707(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768).

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