TTD | Drug: D0K9GG

Drug General Information
Drug ID	D0K9GG
Former ID	DIB020164
Drug Name	L-703,606
Synonyms	L-703606
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539333]
Structure		Download 2D MOL
Formula	C27H29IN2
InChI	InChI=1S/C27H29IN2/c28-24-14-8-7-13-23(24)19-29-26-22-15-17-30(18-16-22)27(26)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-14,22,25-27,29H,15-19H2/t26-,27-/m1/s1
InChIKey	WSLTYZVXORBNLB-KAYWLYCHSA-N
PubChem Compound ID	132629
PubChem Substance ID	29310732, 57344219, 75799363, 85177272, 103194820, 104030318, 104377894, 129627665, 135258984, 135650480, 184527209, 240225418, 252655907
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[534153]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539333	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2104).
Ref 534153	The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. J BiolChem. 1996 Aug 23;271(34):20250-7.

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Drug Information