Drug General Information
Drug ID	D0K9OL
Former ID	DNC001306
Drug Name	SCH 50911
Drug Type	Small molecular drug
Indication	Absence seizures [ICD10:G40]		Terminated	[538658], [545982]
Structure		Download 2D MOL 3D MOL
Formula	C8H15NO3
InChI	InChI=1S/C8H15NO3/c1-8(2)5-12-6(4-9-8)3-7(10)11/h6,9H,3-5H2,1-2H3,(H,10,11)/t6-/m0/s1
InChIKey	SEYCKMQSPUVYEF-LURJTMIESA-N
PubChem Compound ID	5311429
PubChem Substance ID	7980582, 11056500, 11364658, 11367220, 11369782, 11377945, 11495578, 26752005, 39341105, 48317615, 48317616, 57359478, 79366857, 92729839, 114156073, 124886959, 132564022, 134339369, 134340510, 135651028, 142796845, 144204487, 162110891, 162223705, 163060180, 163642568, 164133278, 164843410, 170466891, 170475224, 176224841, 189614597, 198970167, 223519243, 226676213, 241182030, 243856372
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Antagonist	[534893]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538658	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1075).
Ref 545982	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005684)
Ref 534893	Activation of nigral dopamine neurons by the selective GABA(B)-receptor antagonist SCH 50911. J Neural Transm. 1999;106(5-6):383-94.

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