Drug Information

Drug General Information
Drug ID
D0K9PS
Former ID
DIB015095
Drug Name
CHF-5480
Synonyms
CHF-5480; PDE 4 inhibitors (COPD/asthma); PDE 4 inhibitors (COPD/asthma), Chiesi
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Investigative [543404]
Company
Chiesi Farmaceutici SpA
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1(c(ccc(c1)/C(=C/c1c(cncc1Cl)Cl)/OC(=O)[C@H](c1ccc(cc1<br />)CC(C)C)C)OC)OC
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [543404]
Type IV phosphodiesterase Target Info Inhibitor [543406]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [543405]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 543404(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300).
Ref 543404(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300).
Ref 543405(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301).
Ref 543406(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303).

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