Drug Information

Drug General Information
Drug ID
D0KS3X
Former ID
DNC012259
Drug Name
U-89267
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533912]
Structure
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2D MOL

3D MOL
Formula
C18H15N5O2
Canonical SMILES
C1CC1C2=NC(=NO2)C3=C4C5CCC(=O)N5C6=CC=CC=C6N4C=N3
InChI
1S/C18H15N5O2/c24-14-8-7-13-16-15(17-20-18(25-21-17)10-5-6-10)19-9-22(16)11-3-1-2-4-12(11)23(13)14/h1-4,9-10,13H,5-8H2
InChIKey
KIGZWNHARYMTNM-UHFFFAOYSA-N
PubChem Compound ID
9840599
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [533912]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [533912]
Gamma-aminobutyric acid receptor Target Info Inhibitor [533912]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [533912]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 533912J Med Chem. 1994 Mar 18;37(6):758-68.Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor.
Ref 533912J Med Chem. 1994 Mar 18;37(6):758-68.Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor.

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