TTD | Drug: D0KX3C

Drug General Information
Drug ID	D0KX3C
Former ID	DIB021262
Drug Name	ZM-274773
Synonyms	M-274773
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541099]
Structure		Download 2D MOL
Formula	C27H34Cl2N4O2
InChI	InChI=1S/C27H34Cl2N4O2/c1-31(26(34)20-6-3-2-4-7-20)19-22(21-8-9-24(28)25(29)18-21)10-15-32-16-11-23(12-17-32)33-14-5-13-30-27(33)35/h2-4,6-9,18,22-23H,5,10-17,19H2,1H3,(H,30,35)/t22-/m1/s1
InChIKey	SCMPVSAUZONHCN-JOCHJYFZSA-N
PubChem Compound ID	9871234
PubChem Substance ID	14836254, 14860540, 24161888, 45293493, 76218631, 129216441, 140225580, 178102403, 223818216, 227604372
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Antagonist	[531732]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541099	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5778).
Ref 531732	Tachykinin NK2 receptor antagonists. A patent review (2006 - 2010). Expert Opin Ther Pat. 2012 Jan;22(1):57-77.

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Drug Information