Drug Information

Drug General Information
Drug ID
D0L0DC
Former ID
DIB019024
Drug Name
bromo-deaza-SAH
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531451]
Structure
Download
2D MOL
Formula
C15H20BrN5O5S
InChI
InChI=1S/C15H20BrN5O5S/c16-6-3-21(13-9(6)12(18)19-5-20-13)14-11(23)10(22)8(26-14)4-27-2-1-7(17)15(24)25/h3,5,7-8,10-11,14,22-23H,1-2,4,17H2,(H,24,25)(H2,18,19,20)/t7-,8+,10+,11+,14+/m0/s1
InChIKey
DIULHULFPSIBAK-TWBCTODHSA-N
PubChem Compound ID
53339032
PubChem Substance ID
125003924, 163636734, 164135966, 164160551, 178103597
Target and Pathway
Target(s) DOT1L Target Info Inhibitor [532243]
KEGG Pathway Lysine degradation
Transcriptional misregulation in cancer
Reactome PKMTs methylate histone lysines
WikiPathways Histone Modifications
References
Ref 531451DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood. 2011 Jun 23;117(25):6912-22.
Ref 532243Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorg Med Chem. 2013 Apr 1;21(7):1787-94.

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