Drug Information

Drug General Information
Drug ID
D0L0GM
Former ID
DNCL002047
Drug Name
Vilanterol
Drug Type
Small molecular drug
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J45, J40-J44, J47] Approved [524423], [542374], [551871]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C24H33Cl2NO5
InChI
InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1
InChIKey
DAFYYTQWSAWIGS-DEOSSOPVSA-N
PubChem Compound ID
10184665
PubChem Substance ID
15180153, 22579535, 40274235, 80028218, 124490436, 135291438, 137063375, 160677153, 163365084, 163835568, 175268108, 178103925, 210275079, 210280717, 223936788, 226509475, 242700176, 250184675, 251963097, 252224058
ChEBI ID
ChEBI:75037
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Modulator [542374]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 524423ClinicalTrials.gov (NCT01936649) Open-label, Test-retest Study Assessing Reproducibility of Quantitative Measurements of Myocardial Uptake of AdreView.. U.S. National Institutes of Health.
Ref 542374(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7353).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 542374(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7353).

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