Drug Information

Drug General Information
Drug ID
D0L0HG
Former ID
DIB020113
Drug Name
AC1LG8KT
Synonyms
AC1LG8KT; BAS 01816608; TCS JNK 5a
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541261]
Structure
Download
2D MOL
Formula
C20H16N2OS
InChI
InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
InChIKey
WQGDQGAFSDMBLA-UHFFFAOYSA-N
PubChem Compound ID
766949
PubChem Substance ID
992766, 4018368, 7470519, 8208850, 26939631, 43866562, 47705156, 79670004, 88566221, 103534538, 105208243, 109967576, 124350132, 134352749, 134353097, 134964527, 135698329, 136352687, 162011713, 163124250, 164860112, 165248344, 166196494, 174006699, 176485115, 178102618, 180095844, 196400425, 204370502, 210275391, 210281039, 223366710, 223395883, 226521681, 242060002, 251960711, 252156819, 252436256, 252450688, 252472168
Target and Pathway
Target(s) Mitogen-activated protein kinase 10 Target Info Inhibitor [543430]
mRNA of human Jun-N-terminal kinase-2 (JNK2) Target Info Inhibitor [528601]
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
T cell receptor signaling pathway
Choline metabolism in cancer
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
B cell activation
EGF receptor signaling pathway
FAS signaling pathway
FGF signaling pathway
Integrin signalling pathway
Interferon-gamma signaling pathway
Parkinson disease
TGF-beta signaling pathway
Ras Pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Huntington disease
Oxidative stress response
T cell activation
Toll receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
CD40/CD40L signaling
FAS (CD95) signaling pathway
Glucocorticoid receptor regulatory network
FoxO family signaling
p75(NTR)-mediated signaling
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocytewnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
CDC42 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
Rapid glucocorticoid signaling
ErbB1 downstream signaling
ATF-2 transcription factor network
Nephrin/Neph1 signaling in the kidney podocyte
p53 pathway
Downstream signaling in na&#xef
RAC1 signaling pathway
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4
Reactome Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factorsR-HSA-2559580:Oxidative Stress Induced Senescence
Activation of the AP-1 family of transcription factors
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
G13 Signaling Pathway
Insulin Signaling
Wnt Signaling Pathway
MAPK Cascade
Oxidative Stress
Wnt Signaling Pathway and Pluripotency
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Apoptosis
BDNF signaling pathway
Integrin-mediated Cell Adhesion
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
TCR Signaling Pathway
TGF Beta Signaling Pathway
EGF/EGFR Signaling Pathway
TGF beta Signaling Pathway
Wnt Signaling Pathway Netpath
JAK/STAT
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
Regulation of toll-like receptor signaling pathway
References
Ref 541261(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5996).
Ref 528601N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301. Epub 2006 Dec 15.
Ref 543430(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1498).

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