Drug General Information
Drug ID
D0L0ZF
Former ID
DNC003894
Drug Name
VESNARINONE
Drug Type
Small molecular drug
Indication Cardiac failure [ICD10:I50] Approved [551871]
Structure
Download
2D MOL

3D MOL

Formula
C22H25N3O4
Canonical SMILES
COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)<br />OC
InChI
1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)
InChIKey
ZVNYJIZDIRKMBF-UHFFFAOYSA-N
CAS Number
CAS 81840-15-5
PubChem Compound ID
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [530575]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [526678]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
PathWhiz Pathway Muscle/Heart Contraction
Reactome cGMP effects
G alpha (s) signalling eventsR-HSA-1296072:Voltage gated Potassium channels
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBaseWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526678Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5.Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Ref 530575Bioorg Med Chem. 2010 Jan 15;18(2):855-62. Epub 2009 Nov 26.Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors.

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