Drug Information

Drug General Information
Drug ID
D0L2KB
Former ID
DNC011752
Drug Name
RO-145974
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534008]
Structure
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2D MOL

3D MOL
Formula
C17H17N3O3
Canonical SMILES
CCOC(=O)C1=C2C3CCCN3C(=O)C4=CC=CC=C4N2C=N1
InChI
1S/C17H17N3O3/c1-2-23-17(22)14-15-13-8-5-9-19(13)16(21)11-6-3-4-7-12(11)20(15)10-18-14/h3-4,6-7,10,13H,2,5,8-9H2,1H3/t13-/m0/s1
InChIKey
VUSVWZBQTTWZGJ-ZDUSSCGKSA-N
PubChem Compound ID
44264318
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [534008]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 534008J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.
Ref 534008J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.

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