Drug Information

Drug General Information
Drug ID
D0L3MP
Former ID
DCL001054
Drug Name
VRX496
Synonyms
NFV; NLF; Nelfinavir; Nelfinavir Monomethane Sulfonate; AG1343; AG1346; NELFINAVIR MESYLATE AG1343; Nelfinavir (INN); Nelfinavir [BAN:INN]; Nelfinavir [INN:BAN]; Viracept (TN); AG1343 (*Mesylate salt*); Viracept (TM)(*Mesylate salt*); Met-SDF-1.beta. & Nelfinavir; Met-Stromal Cell-derived Factor-1.beta. (Human) & Nelfinavir; (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide; (3S-(2(2S*,3S*),3alpha,4abeta,8abeta))-N-(1,1-Dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-3-isoquinolinecarboxamide; 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE
Drug Type
Antisense drug
Indication Acquired immune deficiency syndrome [ICD9: 42; ICD10:B20] Approved [547684]
Therapeutic Class
Antisense
Company
VIRxSYS Corporation
Structure
Download
2D MOL

3D MOL
Formula
C32H45N3O4S
Canonical SMILES
CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C<br />(=O)NC(C)(C)C)O
InChI
1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1
InChIKey
QAGYKUNXZHXKMR-HKWSIXNMSA-N
CAS Number
CAS 159989-64-7
PubChem Compound ID
64143
PubChem Substance ID
9466, 612304, 644085, 828673, 7885113, 7980103, 8030419, 8189156, 14862000, 14886478, 29211928, 29215104, 29215105, 43121051, 46392782, 46507719, 48426124, 48426125, 48426126, 48426127, 49665993, 49853861, 49986443, 50418709, 53789140, 56320472, 57315038, 85177038, 85177042, 85177050, 91148445, 92717921, 93166553, 93167161, 96024947, 103956869, 104234156, 104330207, 104829285, 124800166, 124889990, 126621876, 126653609, 126681687, 128993952, 131300718, 134337994, 135023001, 137001914, 137261511
SuperDrug ATC ID
J05AE04
Target and Pathway
Target(s) mRNA of HIV-1 envelope protein Target Info [551023]
References
Ref 547684Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018409)
Ref 551023Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.

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